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KMID : 0043320140370040435
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Archives of Pharmacal Research
2014 Volume.37 No. 4 p.435 ~ p.439
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G-protein coupled receptor 40 agonists as novel therapeutics for type 2 diabetes
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Choi Yun-Jung
Shin Dong-Yun
Lee Ju-Yeun
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Abstract
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With growing needs for new antidiabetic drugs which are safe and effective alone or in combination with existing drugs, G-protein coupled receptor 40 (GPR40) has drawn a considerable attention as a potential therapeutic target for type 2 diabetes. As GPR40 agonist may offer advantages to commonly used agents, by acting ambient glucose dependent manner which mechanistically leads to reduced risk of developing hypoglycemia. Since deorphanization in 2003, development of small molecule GPR40 agonists has been spurred by several research groups. There are a number of lead molecules targeting GPR40, and among these molecules TAK-875 (full agonist) and AMG 837 (partial agonist) advanced into clinical stage.
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KEYWORD
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GPR40 agonist, Antidiabetics, Type 2 diabetes mellitus
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